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Preparation, characterization and organ distribution of the oxochloro‐BIS‐(1,10‐phenanthroline)technetium (V) cation
Author(s) -
Schwochau K.,
Linse K. H.,
Pleger P.,
Pleger U.,
Kremer C.,
de Graaf A. A.
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199611)38:11<1031::aid-jlcr919>3.0.co;2-z
Subject(s) - chemistry , phenanthroline , methanol , aqueous solution , ligand (biochemistry) , nuclear chemistry , proton nmr , medicinal chemistry , inorganic chemistry , stereochemistry , organic chemistry , biochemistry , receptor
[TcOCl(phen) 2 ]Cl 2 was prepared by controlled potential cathodic reduction or dithionite reduction of TcO 4 in aqueous alcoholic solution containing 1,10‐phenanthroline(phen) monohydrate. The compound was also obtained by ligand exchange reaction of [TcOCl 4 ] with phen‐H 2 O in methanol. The strong IR absorption at 895 cm −1 was attributed to the Tc = O stretching vibration. The 1 H NMR spectrum displayed 16 distinct resonances which were assigned by HH‐COSY‐experiments to the non‐equivalent aromatic protons of the two phen ligands. The maximum uptake of [ 99m TcOCl(phen) 2 ] 2+ of 4.2% dose/g heart in mice, 1 min p.i., was low, probably reflecting the dipositive charge and the high hydrophilicity of the complex.