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Preparation of carbon‐14 labeled hair dyes: Nitrophenylenediamine
Author(s) -
Fudala Louise,
Lewin Anita H.
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199610)38:10<923::aid-jlcr910>3.0.co;2-i
Subject(s) - chemistry , aniline , nitration , nitric acid , yield (engineering) , sulfuric acid , nuclear chemistry , organic chemistry , medicinal chemistry , metallurgy , materials science
Nitration of N‐ethoxycarbonyl‐[U‐ 14 C]aniline with two equivalents of nitric acid in sulfuric acid afforded N‐ethoxycarbonyl‐2,4‐dinitro‐[U‐ 14 C]aniline which was deprotected quantitatively to 2,4‐dinitro‐[U‐ 14 C]aniline. Selective hydrogenation provided 99.5% radiochemically pure [U‐ 14 C]nitrophenylenediamine with specific activity 25.6 mCi/mmol in 20% radiochemical yield.