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Preparation of carbon‐14 labeled hair dyes: Disperse blue 1
Author(s) -
Berrang Bertold D.,
Lewin Anita H.
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199610)38:10<907::aid-jlcr909>3.0.co;2-v
Subject(s) - chemistry , oleum , bromide , hydrolysis , acylation , yield (engineering) , nuclear chemistry , potassium bromide , friedel–crafts reaction , fluoride , potassium , organic chemistry , inorganic chemistry , catalysis , materials science , metallurgy
Friedel‐Crafts acylation of [U‐ 14 C] p ‐dichlorobenzene with 3,6‐dichlorophthalic anhydride in aluminum bromide melt followed by oleum cyclization afforded [U‐ 14 C]‐1,4,5,8‐tetra‐chloroanthraquinone. Potassium fluoride mediated amidosulfonation followed by hydrolysis gave [U‐ 14 C]‐1,4,5,8‐tetraaminoanthraquinone with specific activity 39.7 mCi/mmol in 5.6% radiochemical yield.