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Probes for narcotic receptor mediated phenomena 22. (1) synthesis and characterization of optically pure [ 3 H](+)‐4‐[(α R )‐α‐((2 S , 5 R )‐4‐propyl‐2,5‐dimethyl‐1‐piperazinyl)‐3‐methoxybenzyl]‐N, N‐diethylbenzamide, [ 3 H]SNC 121, a novel high affinity and selective ligand for delta opioid receptors
Author(s) -
Calderon Silvia N.,
Bertha Craig M.,
Gutkind J. Silvio,
Xu Heng,
Partilla John S.,
Rothman Richard B.,
Rice Kenner C.
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199609)38:9<847::aid-jlcr900>3.0.co;2-n
Subject(s) - chemistry , chemical synthesis , ligand (biochemistry) , opioid receptor , stereochemistry , narcotic antagonists , catalysis , receptor , opioid , medicinal chemistry , combinatorial chemistry , in vitro , organic chemistry , (+) naloxone , biochemistry
The synthesis of unlabelled and labelled SNC 121, a selective nonpeptide ligand for the delta opioid receptor is reported. [ 3 H]SNC 121 of specific activity of 26.8 Ci/mmol, was synthesized by catalytic tritiation of the optically pure precursor SNC 80.