Premium
Synthesis of 3‐deuterated diazepam and nordiazepam 4‐oxides and their use in the synthesis of other 3‐deuterated derivatives
Author(s) -
Yang Shen K.,
Tang Ren,
Pu QuanLong
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199608)38:8<753::aid-jlcr890>3.0.co;2-n
Subject(s) - chemistry , deuterium , oxazepam , methanol , diazepam , enol , tautomer , oxide , organic chemistry , pharmacology , catalysis , biochemistry , benzodiazepine , medicine , physics , receptor , quantum mechanics
The protons at 3‐positions of diazepam 4‐oxide and nordiazepam 4‐oxide underwent an efficient deuterium exchange via keto‐enol tautomerism in deuterated alkaline methanol. The 3‐dideuterated 4‐oxides were each used as a starting material to synthesize 3‐monodeuterated oxazepam and its 3‐acetate, 3‐monodeuterated temazepam and its 3‐acetate, and 3‐dideuterated diazepam and nordiazepam.