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Synthesis of carbon‐14 labelled 1‐[4‐methyl‐3‐mxo‐4‐AZA‐5α‐androstane‐17β‐carbonyl]‐1,3‐diisopropylurea (turosteride), a new 5α‐reductase inhibitor
Author(s) -
Fontana E.,
Angiuli P.,
Pignatti A.,
Panzeri A.,
Dostert P.
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199607)38:7<667::aid-jlcr877>3.0.co;2-2
Subject(s) - chemistry , androstane , yield (engineering) , reductase , carbon 14 , pregnenolone , specific activity , radiochemistry , nuclear chemistry , medicinal chemistry , steroid , stereochemistry , organic chemistry , enzyme , biochemistry , materials science , physics , quantum mechanics , hormone , metallurgy
The synthesis in eight steps of the title compound from the commercially available[20‐ 14 C]pregnenolone 1 is described. The expected 1‐[4‐methyl‐3‐oxo‐4‐aza‐5α‐androstane‐17β‐[ 14 C]carbonyl]‐1,3‐diisopropylurea ([ 14 C]FCE 26073) was obtained with a radiochemical purity higher than 97% and a specific activity of 2.03 GBq/mmol. An overall radiochemical yield of 21% was achieved from 1.