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Oxidative chlorination of [U‐ 14 C] phenol
Author(s) -
Georgin D.,
de SuzzoniDezard S.,
Noel J. P.
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199607)38:7<645::aid-jlcr879>3.0.co;2-4
Subject(s) - chemistry , phenol , oxidative phosphorylation , 2,4 dichlorophenol , phenols , organic chemistry , medicinal chemistry , nuclear chemistry , biochemistry , biology , bacteria , genetics
The preparation of [U‐ 14 C] 2,4‐dichlorophenol was formerly achieved by a Sandmeyer reaction with [U‐ 14 C] 2,4‐dichloroaniline but this sensitive step gave unreproductive yields in our hands. We describe another route to [U‐ 14 C] 2,4‐dichlorophenol by the oxidative chlorination of [U‐ 14 C] phenol. This shorter route is safer and gives satisfactory yields. The nature of the oxidizer is discussed.