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The first synthesis of [9, amino‐ 15 N 2 ] adenine and β‐2′‐deoxy‐[9, amino‐ 15 N 2 ] adenosine
Author(s) -
Orji Charles C.,
Silks Louis A.
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199607)38:7<625::aid-jlcr874>3.0.co;2-p
Subject(s) - chemistry , nucleoside , adenosine , amino acid , stereochemistry , biochemistry
β‐2′‐Deoxy‐[9, Amino‐ 15 N 2 ] Adenosine has been constructed in 4 steps from commercially available 5‐amino‐4,6‐dichloropyrimidine and 15 NH 3 . The reactions have been scaled to provide significant quantities of labeled nucleoside.