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Synthesis and purification of highly tritiated aryldiazonium photoprobes for cholinergic binding sites
Author(s) -
Autelitano F.,
LabatAlcaraz M.L.,
Sobrio F.,
Goeldner M.,
Ilien B.
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199606)38:6<567::aid-jlcr866>3.0.co;2-b
Subject(s) - chemistry , high performance liquid chromatography , chromatography , combinatorial chemistry , radiochemistry
The synthesis and improved purification procedures of two photoactivatable ligands 3 H‐A and 3 H‐B (Figure 1) are presented. Particular attention was given to the use of resolutive reversed‐phase HPLC conditions which were found to be essential for the characterization and the elimination of contaminating products and for the obtention of pure diazonium probes at high specific radioactivity (up to 50 Ci/mmol).