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Synthesis, stability, and radiolytic decomposition of carbon‐14 labeled MK0677
Author(s) -
Jones A.N.,
Dean D.C.,
Jenkins H.J.,
Melillo D.G.,
Nargund R.P.,
Wallace M.A.
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199606)38:6<561::aid-jlcr872>3.0.co;2-s
Subject(s) - chemistry , radiolysis , decomposition , carbon 14 , aqueous solution , carbon fibers , chemical decomposition , nitrogen , dissolution , ethanol , nuclear chemistry , radiochemistry , inorganic chemistry , organic chemistry , physics , materials science , quantum mechanics , composite number , composite material
MK0677 is an orally active growth hormone secretagogue. The crystallized carbon‐14 labeled material was found to undergo radiolytic decomposition via a peroxide intermediate which resulted in loss of the benzyl group. The rate was diminished when the tracer was crystallized from nitrogen‐degassed solvents. Storage stability was best in aqueous ethanol.