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A rapid method for the synthesis of 4‐iodoantipyrine
Author(s) -
Trivedi Mahendra A.
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199605)38:5<489::aid-jlcr857>3.0.co;2-6
Subject(s) - chemistry , electrophile , solid phase extraction , iodide , chloride , halogenation , extraction (chemistry) , chromatography , combinatorial chemistry , high performance liquid chromatography , radiochemistry , organic chemistry , catalysis
A modified method for the synthesis of radioiodinated 4‐ 125 iodoantipyrine based on electrophilic iodination using NaIO 3 as an oxidising agent is described. This straightforward method is reproducible and yields consistently high (>98%) radiolabelled 4 125 IAP. The use of solid phase extraction columns facilitates the removal of excess iodide and chloride ions with consistently high recovery (>80%), simplifies the purification procedure, reduces preparation time and does not require the use of hplc technique.