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Synthesis of 14 C‐labelled satigrel
Author(s) -
Tanaka Shigeru,
Yamagishi Youji,
Kusano Kazutomi,
Yoshimura Tsutomu
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199605)38:5<435::aid-jlcr861>3.0.co;2-5
Subject(s) - chemistry , yield (engineering) , benzophenone , ring (chemistry) , carbon 14 , pharmacokinetics , radiochemistry , high performance liquid chromatography , specific activity , radiosynthesis , chemical synthesis , chromatography , stereochemistry , organic chemistry , pharmacology , in vitro , nuclear medicine , biochemistry , positron emission tomography , enzyme , medicine , materials science , physics , quantum mechanics , metallurgy
14 C‐Labelled satigrel, or 4‐cyano‐5‐(4′‐methoxy [ring‐U‐ 14 C] phenyl)‐5‐(4″‐methoxyphenyl)‐4‐pentenoic acid was synthesized for drug metabolism and pharmacokinetic studies using 4,4′‐dimethoxy [ring‐U‐ 14 C] benzophenone as the starting material. The radiochemical yield was 10.0%. The specific radioactivity and radiochemical purity, as determined by radio‐HPLC analysis, were 10.3 MBq(277.2 μCi)/mg and 98.8%, respectively.