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Regioselective synthesis of deuterated analogs of the neurotoxin MPTP
Author(s) -
Mabic Stéphane,
Castagnoli Neal
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199603)38:3<255::aid-jlcr835>3.0.co;2-0
Subject(s) - mptp , chemistry , regioselectivity , neurotoxin , deuterium , yield (engineering) , stereochemistry , medicinal chemistry , organic chemistry , catalysis , biochemistry , parkinson's disease , physics , materials science , quantum mechanics , metallurgy , medicine , disease , pathology
1‐Methyl‐4‐phenyl‐2‐pyridone has been used as starting material for the efficient and regioselective synthesis of deuterated analogues of the neurotoxin 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP). MPTP‐2,2‐ d 2 , MPTP‐6,6‐ d 2 and MPTP‐2,2,6,6‐ d 4 were obtained in good yield through a combination of alkaline deuterium exchange and selective LiAIH 4 and LiAID 4 reduction reactions.