Premium
Preparation of high specific activity [15,16‐ 3 H]‐7‐benzylidenenaltrexone
Author(s) -
Lewin Anita H.,
Lamb Pamela B.
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199602)38:2<203::aid-jlcr828>3.0.co;2-d
Subject(s) - chemistry , specific activity , benzaldehyde , yield (engineering) , naltrexone , dilution , aldol condensation , ligand (biochemistry) , tritium , radiochemistry , nuclear chemistry , chromatography , organic chemistry , catalysis , biochemistry , receptor , antagonist , enzyme , materials science , physics , nuclear physics , metallurgy , thermodynamics
The preparation of the δ 1 ‐specific ligand 7‐benzylidenenaltrexone (BNTX), labeled with tritium at high specific activity (14.4 Ci/mmol) was prepared in 33% yield and >98% purity by the aldol condensation of high specific activity [15,16‐ 3 H]naltrexone with benzaldehyde at high dilution.