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Pesticides labelled with 14 C III. Synthesis of [6‐ 14 C]metribuzine
Author(s) -
Koltai Ernö,
Kling Ferenc,
Rutkai György
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199602)38:2<169::aid-jlcr818>3.0.co;2-s
Subject(s) - chemistry , yield (engineering) , acetic acid , pyruvic acid , sodium , medicinal chemistry , sodium pyruvate , pesticide , radiochemistry , stereochemistry , nuclear chemistry , organic chemistry , biochemistry , materials science , agronomy , metallurgy , biology
14 C labelled Metribuzine was synthetised in a five step synthesis from sodium [1‐ 14 C]pivalate (trimethyl acetic acid) via o‐bromo‐[2‐ 14 C]pinacoline (1‐bromo‐3,3‐dimethyl‐butan‐2‐on) and trimethyl [2–14C]pyruvic acid. The total yield was 30% (calculated on sodium pivalate).