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Synthesis of a radiolabelled new oral cephalosporin, E1101
Author(s) -
Negi Shigeto,
Komatsu Yuki,
Tsuruoka Akihiko,
Uemura Yuji
Publication year - 1996
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/(sici)1099-1344(199601)38:1<1::aid-jlcr808>3.0.co;2-n
Subject(s) - chemistry , cephalosporin , thiourea , ring (chemistry) , broad spectrum , stereochemistry , antibacterial agent , combinatorial chemistry , chemical synthesis , pharmacology , organic chemistry , biochemistry , antibiotics , in vitro , medicine
The new broad‐spectrum oral antibacterial agent, E1101, has been labelled in the C‐2 position of the aminothiazole ring using [ 14 C]thiourea. The cephalosporin analog was synthesized in 5 steps and is suitable for metabolism and disposition studies.