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Effects of intermittent exposures of aflatoxin B 1 on hepatic and testicular glutathione S‐transferase in rats
Author(s) -
Sahu Saura C.,
Chou Ming W.,
Sotomayor Rene E.,
Hinton Dennis M.,
Barton Curtis N.,
O'Donnell Michael W.
Publication year - 2000
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(200005/06)20:3<215::aid-jat649>3.0.co;2-2
Subject(s) - aflatoxin , glutathione , glutathione s transferase , endocrinology , chemistry , toxicity , biology , medicine , toxicology , enzyme , biochemistry , food science
Glutathione S ‐transferase (GST) plays a major role in the detoxification of the potent hepatocarcinogen aflatoxin B 1 (AFB 1 ). This study evaluated the effects of intermittent exposures to AFB 1 on hepatic and testicular GST in rats. Male Fischer 344 rats were fed diets containing AFB 1 (0, 0.01, 0.04, 0.4 and 1.6 ppm) intermittently at 4‐week intervals up to 20 weeks. The control animals were fed an AFB 1 ‐free NIH‐31 diet. Rats consuming diets with 0.01 ppm AFB 1 did not show the induction of hepatic or testicular GST activity. Intermittent exposures to AFB 1 at concentrations of 0.04–1.6 ppm significantly increased the GST activities. The increase of the enzyme activity was proportional to the dose and length of AFB 1 exposure. Copyright © 2000 John Wiley & Sons, Ltd.