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Effects of lead(II) nitrate and a dithiocarbamate fungicide on the rat lung
Author(s) -
Adamis Zoltán,
Tátrai Erzsébet,
Honma Koichi,
Ungváry György
Publication year - 1999
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199909/10)19:5<347::aid-jat587>3.0.co;2-3
Subject(s) - chemistry , toxicity , lactate dehydrogenase , nitrate , fungicide , pulmonary toxicity , lung , dithiocarbamate , biochemistry , bronchoalveolar lavage , pharmacology , toxicology , environmental chemistry , enzyme , biology , medicine , organic chemistry , botany
The pulmonary toxicity of two potential environmental pollutants was studied in rats 1, 7 and 30 days after a single intratracheal instillation of lead nitrate and Dithane M‐45 (mancoceb), either individually or in various combinations. The cell count, protein, phospholipids and lactate dehydrogenase level were determined in the bronchoalveolar lavage fluid, as were the protein, phospholipids and acid phosphatase contents in the lung tissue. Lead nitrate and Dithane M‐45 induced acute inflammation reactions with different features. The effects of mixtures of lead nitrate and Dithane M‐45 were found to be different from those of the individual components. Copyright © 1999 John Wiley & Sons, Ltd.