Premium
Ochratoxicosis: prevention of developmental toxicity by L‐methionine in rats
Author(s) -
AbdelWahhab M. A.,
Nada S. A.,
Arbid M. S.
Publication year - 1999
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199901/02)19:1<7::aid-jat529>3.0.co;2-g
Subject(s) - toxicity , methionine , developmental toxicity , toxicology , medicine , biology , genetics , pregnancy , fetus , amino acid
l‐Methionine was found to inhibit the developmental toxicity induced by ochratoxin A (OA) in pregnant female rats. The fetuses had significantly lower weights. Dams and fetuses treated with OA had visceral and skeletal anomalies, while combined treatment with l‐methionine and OA showed no significant changes when compared to the control. Histopathological examinations revealed that OA caused alterations in liver, kidney and vagina of pregnant rats, whereas methionine supplementation provided partial protection for renal and liver tissue. Copyright © 1998 John Wiley & Sons, Ltd.