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Hexachlorocyclohexane‐induced behavioural and neurochemical changes in rat
Author(s) -
Sahoo Arjun,
Samanta Luna,
Das Alaka,
Patra Sarat K.,
Chainy Gagan B. N.
Publication year - 1999
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199901/02)19:1<13::aid-jat531>3.0.co;2-e
Subject(s) - neurochemical , acetylcholinesterase , hexachlorocyclohexane , aché , atpase , chemistry , open field , medicine , enzyme , endocrinology , biochemistry , biology , pesticide , ecology
Effect of chronic oral exposure (10 and 20 mg kg −1 body wt. for 7, 15 and 30 days) to hexachlorocyclohexane (HCH) on open‐field behaviour and activities of cerebral Na + ,K + ‐ATPase, Mg 2+ ‐ATPase and acetylcholinesterase (AChE) of rat was evaluated. Motor and grooming activities were altered, whereas vertical exploratory activity was unaffected by HCH. Activities of Na + ,K + ‐ATPase, Mg 2+ ‐ATPase and AChE were inhibited significantly by the pesticide. The results suggest that HCH induces impairment of the enzymes involved in synaptic activity, resulting in behavioural alterations. Copyright © 1998 John Wiley & Sons, Ltd.