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Differential effects of organometallic tin compounds on Na + /K + ‐ATPase activity
Author(s) -
Samuel Purnima M.,
Roy Sujit,
Jaiswal K. Aradhana,
Rao J. Venkateswara
Publication year - 1998
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(1998090)18:5<383::aid-jat523>3.0.co;2-0
Subject(s) - chemistry , isothiocyanate , chloride , potency , ic50 , atpase , tin , in vitro , group 2 organometallic chemistry , medicinal chemistry , stereochemistry , biochemistry , enzyme , organic chemistry , molecule
In vitro effects of six dibenzyltin dichloride (A‐series) and another six dibenzyltin diisothiocyanate (B‐series) complexes on Na + /K + ‐ATPase were studied. The rat brain synaptic membranes were prepared and significant ATPase inhibition was observed with all the complexes in a dose‐dependent manner. The order of potency on Na + /K + ‐ATPase activity of the chloride complexes was found to be higher than that of the isothiocyanate complexes. The IC 50 values range from 64 μM to 252 μM for the chloride complexes and from 132 μM to 399 μM for the isothiocyanate complexes. A structure–activity relationship could be derived for the chloride complexes. © 1998 John Wiley & Sons, Ltd.