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Role of ascorbic acid in cadmium‐induced thyroid dysfunction and lipid peroxidation
Author(s) -
Gupta Pratima,
Kar Anand
Publication year - 1998
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(1998090)18:5<317::aid-jat514>3.0.co;2-u
Subject(s) - lipid peroxidation , triiodothyronine , endocrinology , medicine , cadmium , ascorbic acid , chemistry , thyroid , hormone , oxidative stress , food science , organic chemistry
A study on the effects of ascorbic acid (AA) on heavy metal (cadmium)‐induced thyroid dysfunction and lipid peroxidation (LPO) was carried out in Swiss male mice. The animals were administered with either cadmium (1.0 mg kg −1 body wt.) alone or in combination with AA (1 mM) every day for 15 days. While cadmium treatment led to a decrease in the serum concentrations of thyroid hormones and hepatic type I iodothyronine 5′‐monodeiodinase (5′D‐I) activity, an increase in the level of lipid peroxidation was observed. The metal‐induced decrease in hepatic 5′D‐I activity and serum triiodothyronine (T 3 ) concentration was restored by treatment with AA. However, AA could not restore the serum thyroxine (T 4 ) concentration. The increased level of LPO was also ameliorated by AA. It appears that the protective effect of AA against cadmium‐induced thyroid dysfunction is mediated through its antioxidative action. © 1998 John Wiley & Sons, Ltd.