Premium
Developmental toxicity of purified fumonisin B 1 in pregnant Syrian hamsters
Author(s) -
Penner Jocelyn D.,
Casteel Stan W.,
Pittman Louis,
Rottinghaus George E.,
Wyatt Roger D.
Publication year - 1998
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199805/06)18:3<197::aid-jat497>3.0.co;2-r
Subject(s) - fumonisin b1 , mycotoxin , fetus , toxicity , fusarium , toxicant , fumonisin , developmental toxicity , gestation , biology , physiology , andrology , pregnancy , toxicology , medicine , food science , botany , genetics
The purpose of this study was to characterize the developmental toxicity of fumonisin B 1 (FB 1 ), a mycotoxin produced by Fusarium moniliforme , on fetal Syrian hamsters. Fusarium moniliforme has been associated with a variety of diseases in animals and esophageal cancer in humans. Purified FB 1 causes leukoencephalomalacia in horses and is hepatocarcinogenic in rats. Fumonisin B 1 has been associated with fetal toxicity in rats and mice and has been suggested to be involved in reproductive failure in pregnant sows. Results from a preliminary developmental toxicity study using an aqueous extract of F. moniliforme corn‐culture material in hamsters suggested that FB 1 was a developmental toxicant. These results were verified using purified FB 1 . Six groups of ten time‐mated female Syrian hamsters were dosed with 0.0–18 mg kg −1 day −1 of FB 1 by gavage on days 8–12 of gestation and euthanized on day 15. Live fetuses were weighed and examined for gross external and internal abnormalities and skeletal anomalies. Purified fumonisin B 1 was shown to cause dose‐dependent fetal death and delayed fetal development without causing fetal abnormalities. © 1998 John Wiley & Sons, Ltd.