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Effect of lithium on hepatic lipid peroxidation and antioxidative enzymes under different dietary protein regimens
Author(s) -
Tandon Aparna,
Dhawan D. K.,
Nagpaul J. P.
Publication year - 1998
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199805/06)18:3<187::aid-jat495>3.0.co;2-y
Subject(s) - catalase , medicine , endocrinology , lithium (medication) , lipid peroxidation , superoxide dismutase , glutathione peroxidase , lithium carbonate , chemistry , antioxidant , enzyme , biochemistry , biology , ion , organic chemistry , ionic bonding
Lithium in the form of lithium carbonate was administered at a dose level of 1.1 g kg −1 food to rats fed normal (18% protein), low‐protein (LP; 8%) and high‐protein (HP; 30%) diets for a period of 1 month. A highly significant (53%) increase in the level of lipid peroxidation (LPO) was observed in protein‐deficient rats but this increase was marginal in rats fed an HP diet (18%). Lithium treatment of rats fed a normal diet caused a marked decrease (22%) in LPO. Lithium administration to rats fed an LP diet also reduced the raised levels of LPO to the extent of 16%. Furthermore, lithium treatment normalized the HP‐induced increase in the levels of LPO. The activities of glutathione peroxidase (GPx), catalase and superoxide dismutase (SOD) were reduced significantly in protein‐deficient rats. On the other hand, an HP diet caused a decrease in SOD activity only. The activities of GPx and catalase were appreciably enhanced in lithium‐treated rats. Lithium treatment to LP‐fed rat markedly increased GPx activity and brought the decreased levels of SOD and catalase to within normal limits. Lithium administration to HP‐fed rats did not cause any significant alteration in the activities of these antioxidative enzymes. © 1998 John Wiley & Sons, Ltd.