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Combined pulmonary toxicity of diethyldithiocarbamate and lead (II) oxide in rats
Author(s) -
Tátrai Erzsébet,
Náray Miklós,
Brózik Márta,
Adamis Zoltán,
Ungváry György
Publication year - 1998
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199801/02)18:1<33::aid-jat467>3.0.co;2-x
Subject(s) - toxicity , pulmonary toxicity , lung , chemistry , pharmacology , bronchoalveolar lavage , sodium diethyldithiocarbamate , lead acetate , lead poisoning , immune system , pathology , immunology , medicine , organic chemistry , psychiatry
The pulmonary toxicity of sodium diethyldithiocarbamate and lead(II) oxide alone or in combination was studied in rats after a single intratracheal instillation. The lead content in the lungs and the whole blood was determined and it has been found that the clearance of lead from the lung was delayed by dithiocarbamate complex formation, which probably had a role in increased IgA levels in the bronchoalveolar fluid and the induction of local immune response. The combined exposure gave rise to calcium deposits in the lungs both extra‐ and intracellularly after 1 month of exposure. Both separate and combined exposure invoked permanent injury in membranes or dystrophic changes in the cytoplasm of pneumocytes, which may initiate and generate a series of events leading to fibrosing alveolitis. © 1998 John Wiley & Sons, Ltd.