Premium
Effect of topically applied sulphur mustard on guinea pig liver
Author(s) -
Chauhan R. S.,
Murty L. V. R.
Publication year - 1997
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199711/12)17:6<415::aid-jat465>3.0.co;2-d
Subject(s) - transaminase , sulfur mustard , pathological , carcinogen , steatosis , guinea pig , elevated transaminases , toxicity , pharmacology , chemistry , toxicology , medicine , physiology , endocrinology , biochemistry , pathology , biology , enzyme
The study revealed that topically applied sulphur mustard, which is a potent blistering agent with mutagenic and carcinogenic properties, is also hepatotoxic. It produces severe steatosis and other pathological alterations, accompanied by biochemical changes. There is a significant rise in the levels of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvate transaminase (GPT) after exposure. The liver injury appeared to peak on the third day. Recovery at the ultrastructural level could be noticed on the sixth day but was far from complete because the gross pathological changes were still severe. © 1997 John Wiley & Sons, Ltd.