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Effect of lipoic acid administration on gentamicin‐induced lipid peroxidation in rats
Author(s) -
Sandhya P.,
Varalakshmi P.
Publication year - 1997
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199711/12)17:6<405::aid-jat459>3.0.co;2-3
Subject(s) - lipid peroxidation , malondialdehyde , glutathione peroxidase , chemistry , nephrotoxicity , pharmacology , glutathione , superoxide dismutase , antioxidant , lipoic acid , kidney , biochemistry , endocrinology , medicine , enzyme
Abstract The intraperitoneal administration of gentamicin (100 mg kg −1 day −1 ) to rats is associated with an increased production of malondialdehyde (MDA), which is an end product of lipid peroxidation in the kidney. The level of glutathione (GSH) and the activity of three antioxidant systems—superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)—were also decreased in the kidney. The liver, however, did not show any such alterations. Gentamicin (100 mg kg −1 day −1 ) plus lipoic acid administration (25 mg kg −1 day −1 ) by gastric intubation brought about a decrease in the degree of lipid peroxidation. An increase in the GSH level and in the activity of SOD, CAT and GPx was also observed. From these observations it can be concluded that administration of DL‐α‐lipoic acid prevents lipid peroxidation, which may, at least partly, play an important role in the injury cascade of gentamicin‐induced nephrotoxicity. © 1997 John Wiley & Sons, Ltd.