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Vitamin C supplementation on hepatic oxidative stress induced by cigarette smoke
Author(s) -
Helen A.,
Vijayammal P. L.
Publication year - 1997
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199709)17:5<289::aid-jat448>3.0.co;2-9
Subject(s) - chemistry , malondialdehyde , antioxidant , oxidative stress , lipid peroxidation , glutathione , vitamin e , glutathione peroxidase , vitamin , superoxide dismutase , catalase , vitamin c , endocrinology , medicine , lipid peroxide , biochemistry , food science , enzyme
A study has been conducted to investigate whether the oxidative damage produced in the liver of rats exposed to cigarette smoke can be effectively combated with vitamin C, one of the antioxidant vitamins. We assessed the liver antioxidants (vitamins E, C and A), scavenging enzymes and lipid peroxide products of rats exposed to cigarette smoke and simultaneously given vitamin C (200 mg 100 g −1 body wt.) for 90 days. Malondialdehyde (MDA), conjugated dienes, hydroperoxides and free fatty acids (FFA) were significantly increased in liver of smoke‐exposed groups. The activity of superoxide dismutase and catalase and vitamin E and C contents were significantly lower than controls. But vitamin A, glutathione (GSH) content and glutathione peroxidase (GSH Pxase) activity were enhanced. Vitamin C supplementation to smoke‐exposed rats showed increased resistance to lipid peroxidation and increased activity of scavenging enzymes. The GSH content, vitamin C and FFA were brought to normal levels. Thus, this study seems to suggest that an intake of a mega dose of vitamin C can protect the liver from oxidant damage caused by cigarette smoke. © 1997 John Wiley & Sons, Ltd.