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Dual Role of Testosterone in Fenvalerate‐treated Mice with Respect to Thyroid Function and Lipid Peroxidation
Author(s) -
Maiti Prasanta Kumar,
Kar Anand
Publication year - 1997
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199703)17:2<127::aid-jat418>3.0.co;2-5
Subject(s) - medicine , thyroid function , endocrinology , lipid peroxidation , testosterone (patch) , fenvalerate , thyroid , chemistry , biology , oxidative stress , pesticide , agronomy
Effects of testosterone propionate (TP, 2.5 mg kg −1 body weight) in fenvalerate‐induced (120 mg kg −1 body weight) thyroid dysfunction and lipid peroxidation were investigated in male mice. Testosterone propionate aggravated in the inhibition of hepatic type I iodothyronine 5′‐monodeiodinase (5′D‐I) activity, coupled with a decrease in serum triiodothyronine (T 3 ) concentration in pesticide‐treated mice. However, it could ameliorate the toxicity as indicated by decreased hepatic lipid peroxidation (LPO) with a marginal but significant increase in superoxide dismutase and catalase activities following fenvalerate treatment. While protective effects of testosterone on LPO indicated its antiperoxidative property, the decrease in 5′D‐I activity could be because of the increased accumulation of fenvalerate in the tissues following TP administration. © 1997 by John Wiley & Sons, Ltd.