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Racemic ‐2,3‐dimercaptosuccinic Acid for Inorganic Mercury Mobilization in Rats
Author(s) -
Kostial K.,
RestekSamaržija N.,
Blanuša M.,
Piasek M.,
Prester Lj.,
Jones M. M.,
Singh P. K.
Publication year - 1997
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199701)17:1<71::aid-jat395>3.0.co;2-u
Subject(s) - dimercaptosuccinic acid , mercury (programming language) , chemistry , mobilization , environmental chemistry , stereochemistry , organic chemistry , medicine , urinary system , computer science , programming language , archaeology , history
The efficiency of racemic ‐2,3‐dimercaptosuccinic acid ( rac ‐DMSA) compared with meso ‐2,3‐dimercaptosuccinic acid ( meso ‐DMSA) in mobilizing inorganic mercury was evaluated in female rats. Chelators were administered orally at a dose of 0.5, 1.0 or 2.0 mmol kg −1 on four consecutive days, 5 days after a single intraperitoneal 203 Hg injection (with 0.5 mg HgCl 2 kg −1 ). Both chelators reduced 203 Hg retention in whole body and kidney and at higher doses also in the liver. Racemic ‐DMSA was more efficient at lower dose levels and equal to meso ‐DMSA at the highest dose level. Kidney retention decreased after rac ‐DMSA to 27, 10 and 10% of controls and after meso ‐DMSA to 68, 39 and 10% of control values at the 0.5, 1.0 and 2.0 mmol kg −1 dose level, respectively. Since meso ‐DMSA is already approved for human use, its stereoisomeric form, rac ‐DMSA, deserves further attention for treatment of mercury poisoning. © 1997 by John Wiley & Sons, Ltd.