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Effect of Prenatal Aluminium Lactate Exposure on Conditioned Taste Aversion and Passive Avoidance Task in the Rat
Author(s) -
Gonda Zsuzsanna,
Lehotzky Kornélia
Publication year - 1996
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199611)16:6<529::aid-jat392>3.0.co;2-s
Subject(s) - litter , taste aversion , weaning , zoology , distilled water , endocrinology , taste , medicine , body weight , saccharin , gestation , pregnancy , chemistry , biology , food science , ecology , genetics , chromatography
Pregnant SPRD rats were injected s.c. daily with 2.45, 4.9 and 9.8 mg kg −1 aluminium lactate or distilled water on gestational days 7–15. Gestational aluminium treatment had no effect either on litter size or the body weight of pups on postnatal day 1 but it decreased postnatal weight gain resulting in significantly lower body weight at weaning (postnatal day 22). It had no effect on the acquisition of a conditioned taste aversion, but in a passive avoidance task the learning ability of pups of dams given the top dose of aluminium was impaired.