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In Vivo Pulmonary Toxicity of Cellulose in Rats
Author(s) -
Tátrai Erzsébet,
Brozik Márta,
Adamis Zoltán,
Merétey Katalin,
Ungváry György
Publication year - 1996
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199603)16:2<129::aid-jat316>3.0.co;2-c
Subject(s) - bronchoalveolar lavage , pulmonary fibrosis , pulmonary toxicity , pathology , lung , fibrosis , toxicity , in vivo , medicine , pulmonary function testing , alveolar epithelium , epithelium , biology , microbiology and biotechnology
Cellulose after a single intratracheal dose (15 mg per animal) brought about fibrosing granulomatous alveobronchiolitis and an increase of IgA production in the bronchoalveolar lavage. Fibrosing alveolitis showed moderate progression as a function of time. With different morphological methods, injury of type I pneumocytes and the incomplete repair of type II pneumocytes were detected. The damage of the alveolar epithelium initiated and activated a series of processes that led to definite pulmonary alterations: pulmonary fibrosis leading to the disintegration of the alveolo‐capillary morphological functional unit.