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Comparative Developmental Toxicity of Di‐, Tri‐ and Tetrabutyltin Compounds after Administration during Late Organogenesis in Rats
Author(s) -
Ema Makoto,
Kurosaka Reiko,
Amano H.,
Ogawa Yoshiyuki
Publication year - 1996
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199601)16:1<71::aid-jat313>3.0.co;2-b
Subject(s) - developmental toxicity , fetus , toxicity , teratology , pregnancy , weight gain , body weight , organogenesis , incidence (geometry) , medicine , endocrinology , physiology , biology , biochemistry , genetics , physics , gene , optics
Abstract Dibutyltin dichloride (DBT), tributyltin chloride (TrBT) and tetrabutyltin (TeBT) were compared for their developmental toxicity and teratogenic potential following administration during the susceptible period for teratogenesis of TrBT. Pregnant rats were given either DBT or TrBT at a dose of 165 or 330 μmol kg−1 or TrBT at a dose of 330, 660, 1320, 2640 or 5280 μmol kg−1 on days 13–15 of pregnancy. Treatment with DBT at 165 and 330 μmol kg−1 caused a significant decrease in the maternal body weight gain. A significant decrease in the fetal weight occurred at 165 and 330 μmol kg−1. No significantly increased incidences of postimplantation loss or of fetuses with malformations were found following treatment with DBT. Treatment with TrBT at 165 and 330 μmol kg−1 resulted in a significant decrease in the maternal weight gain. A significant decrease in the fetal weight was found at 330 μml kg−1. A significantly and markedly increased incidence of fetuses with cleft palate was noted in both groups treated with TrBT. Treatment with TeBT caused a significantly decreased maternal body weight gain at doses of 660 μmol kg−1 and above. A significantly increased incidence of fetuses with cleft palate was observed at a dose of 5280 μmol kg−1. It could be concluded that there is a difference in the manifestation and degree of developmental toxicity between DBT, TrBT and TeBT.