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Renal and Spermatozoal Toxicity of α‐Bromohydrin, 3‐Bromolactate and 3‐Bromopyruvate
Author(s) -
Jones A. R.,
Porter K. E.,
Dobbie M. S.
Publication year - 1996
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199601)16:1<57::aid-jat305>3.0.co;2-r
Subject(s) - toxicity , kidney , endocrinology , in vitro , medicine , boar , diuresis , metabolism , chemistry , biology , andrology , biochemistry , sperm
(R,S)‐ and (R)‐3‐Bromopropan‐1,2‐diol (α‐bromohydrin) produced diuresis and glucosuria when administered to male rats but had no effect on the metabolic activity of rat kidney tubules in vitro. The oxidation products (R,S)‐3‐bromolactate and 3‐bromopyruvate produced brief phases of diuresis but not glucosuria, and severely inhibited the metabolic activity of rat kidney tubules in vitro. α‐Bromohydrin had no effect on the metabolic activity of boar spermatozoa whereas the oxidation products severely affected mitochondrial metabolism. 3‐Bromopyruvate also inhibited boar spermatozoal glyceraldehyde 3‐phosphate dehydrogenase.