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Nephrotoxic Effects of Unleaded Petrol in Female Rats
Author(s) -
Vyskocil A.,
Cizkova M.
Publication year - 1996
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199601)16:1<55::aid-jat312>3.0.co;2-4
Subject(s) - lactate dehydrogenase , nephrotoxicity , renal function , endocrinology , excretion , lysozyme , medicine , albumin , urinary system , creatinine , chemistry , kidney , biochemistry , enzyme
Female Wistar rats were exposed to 4 g m−3 unleaded petrol for 8 h a day, 5 days a week for 60 days. Urinary β2‐microglobulin (β2‐m), lactate dehydrogenase (LDH) and lysozyme were used as markers of tubular dysfunction. Urinary excretion of albumin and the glomerular filtration rate (GFR) were used as indicators of glomerular impairment. There were no statistically significant changes in the GFR or urinary albumin concentrations in the exposed group. Petrol exposure induced an increase of β2‐m, total proteins, lysozyme and LDH excretion, but only β2‐m was increased significantly. Our results show that subchronic exposure to high levels of unleaded petrol induced only a mild proximal tubular dysfunction in female rats.