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Cytogenetic Effect of Some Insecticides in Mouse Spleen
Author(s) -
Amer Soheir M.,
Fahmy Maha A.,
Donya Souria M.
Publication year - 1996
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/(sici)1099-1263(199601)16:1<1::aid-jat294>3.0.co;2-a
Subject(s) - malathion , genotoxicity , spleen , toxicology , biology , pesticide , body weight , chemistry , toxicity , immunology , endocrinology , agronomy , organic chemistry
Several insecticides were tested for their ability to induce chromosomal aberrations in mouse spleen. They were injected i.p. in doses representing approximately 1/8–1/10 of the respective ld50 values. Doses were: DDT, 5.5 mg kg−1 body wt.; malathion, 30 mg kg−1 body wt.; Dursban, 4 mg kg−1 body wt.; Sevin, 7 mg kg−1 body wt.; and Lannate, 1 mg kg−1 body wt. ‘Mitomycin C’ at a dose of 1 mg kg−1 body wt. was used as a positive control. Mice were sacrificed 6, 24 and 48 h after treatment. DDT, malathion, dursban and lannate caused maximum chromosomal aberrations 24 h after injection, whereas Sevin induced its maximum effect 6 h after the treatment. All the insecticides induced statistically significant chromosomal aberrations even after excluding the number of metaphases with gaps. The results indicate genotoxicity in mouse spleen cells.