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Decreased awareness of cognitive deficits in patients with mild dementia of the Alzheimer type
Author(s) -
Derouesné Christian,
Thibault Stéphanie,
LaghaPierucci Samira,
BaudouinMadec Véronique,
Ancri Daniel,
Lacomblez Lucette
Publication year - 1999
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/(sici)1099-1166(199912)14:12<1019::aid-gps61>3.0.co;2-f
Subject(s) - dementia , alzheimer's disease , cognition , psychology , degenerative disease , psychiatry , gerontology , medicine , central nervous system disease , clinical psychology , disease , neuroscience
Objective To study the unawareness of cognitive deficits in patients with mild dementia of Alzheimer type (DAT). Design Retrospective study. We surveyed the medical records of outpatients meeting the NINCDS–ADRDA criteria for probable DAT who were able to complete the Cognitive Difficulties Scale (CDS) and had a close informant relative (IR) who could complete the family form of the same questionnaire. Setting A department of neurology in a general teaching hospital. Subjects Eighty‐eight patients, aged 73.2±8.6 years with a mean MMSE score of 22.5±3.2. Fifty‐two of the 88 patients had a follow‐up examination after a mean interval of 21 months. Methods Awareness of cognitive deficits was mainly assessed as the difference between the scores on the CDS completed by the IR and the patient (Index of Unawareness, IU). Two secondary assessments of unawareness were performed: (1) an assessment by the clinician on the basis of the patient's answers to questions probing the awareness of memory deficits; (2) an evaluation by the IR of the frequency of behavioural manifestations of unawareness in everyday life. SPECT was performed in 78 patients to study the relationship between unawareness and the topography of perfusion deficits. Results Awareness of the cognitive deficits varied greatly between patients, according to the assessment method used and the stage of progression of the disease. Most patients with mild DAT were cognitively aware of their cognitive deficits but failed to appraise their severity and their consequences in everyday life. Decreased awareness was positively correlated with age and perfusion deficits in the frontal regions and negatively with the anxious symptomatology. However, the main correlate of unawareness was apathy. Conclusion The nature of unawareness of cognitive deficits appeared to be more dimensional than categorical. In patients with mild dementia, decreased awareness appeared to be more related to affective disturbances, especially to emotional deficit or apathy, than to cognitive deficits. Copyright © 1999 John Wiley & Sons, Ltd.