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VARIABLES WHICH DISTINGUISH PATIENTS FULFILLING CLINICAL CRITERIA FOR DEMENTIA WITH LEWY BODIES FROM THOSE WITH ALZHEIMER'S DISEASE
Author(s) -
GRAHAM CANDIDA,
BALLARD CLIVE,
SAAD KARIM
Publication year - 1997
Publication title -
international journal of geriatric psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 129
eISSN - 1099-1166
pISSN - 0885-6230
DOI - 10.1002/(sici)1099-1166(199703)12:3<314::aid-gps487>3.0.co;2-7
Subject(s) - dementia with lewy bodies , dementia , degenerative disease , disease , psychology , alzheimer's disease , lewy body disease , central nervous system disease , psychiatry , medicine , neuroscience , pathology
Objectives . To compare patients fulfilling clinical criteria for Lewy body dementia with those meeting clinical criteria for Alzheimer's disease. Design . Prospective cohort study. Setting . Psychiatric services and a memory clinic. Sample . 124 patients with DSM‐III‐R dementia. Measures . The assessment included the GMS/HAS/SDS package, the CAMCOG, the Cornell Depression scale and the Burns Symptom Checklist. Dementia was diagnosed according to DSM‐III‐R, NINCDS ADRDA, McKeith, Byrne, Hachinski and HAS AGECAT criteria. Results . Patients meeting McKeith et al . criteria for senile dementia of Lewy body type were significantly more likely to have clouding of consciousness, significant Parkinsonian symptoms and less severely impaired recent memory than patients with NINCDS ADRDA Alzheimer's disease. Each of these variables also distinguished patients meeting Byrne et al .'s criteria for dementia with Lewy bodies from those with a diagnosis of Alzheimer's disease. Conclusions . It is suggested that one set of criteria could encompass those overlapping groups of patients. Work is needed to further develop the diagnostic criteria for Lewy body dementia. © 1997 by John Wiley & Sons, Ltd.