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Melatonin sensitivity to dim white light in different seasons
Author(s) -
Nathan Pradeep J.,
Burrows Graham D.,
Norman Trevor R.
Publication year - 1999
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/(sici)1099-1077(199901)14:1<53::aid-hup69>3.0.co;2-6
Subject(s) - melatonin , circadian rhythm , nocturnal , photoperiodism , endocrinology , white light , affect (linguistics) , medicine , hormone , light pollution , pineal gland , biology , trait , artificial light , zoology , psychology , physics , optics , communication , illuminance , computer science , programming language
It is well known that the pineal hormone melatonin is suppressed by light. The melatonin suppression by dim light has also been suggested as a possible trait marker of bipolar disorder. However, there is large inter individual differences in the light responses. It is possible that methodological factors may contribute to the variable responses observed. Most studies in the past have been conducted in different seasons under different lighting conditions. It is possible the external lighting conditions may affect the melatonin suppression to dim light. Hence we examined the melatonin suppression by dim light in (1) a large group of subjects randomly tested once in one of the four seasons (part one) and (2) small group of subjects tested in all seasons (part two). Subjects were placed in a dark room from 2100 h to 0230 h. Light exposure was between midnight and 0100 h in a sitting position. Blood samples were collected at regular intervals for measurement of plasma melatonin. No statistically significant seasonal differences in the percentage suppression of melatonin were found in both parts of the study ( p >0·5). The study suggests that seasonal changes in external lighting do not affect the melatonin suppression by dim light in healthy controls. Copyright © 1999 John Wiley & Sons, Ltd.