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Selective serotonin re‐uptake inhibitors in the treatment of self‐injurious behaviour in adults with mental retardation
Author(s) -
Singh Ashok N.,
Kleynhans Daleen,
Barton Gerta
Publication year - 1998
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/(sici)1099-1077(199806)13:4<267::aid-hup994>3.0.co;2-2
Subject(s) - fluvoxamine , fluoxetine , serotonin , psychology , adverse effect , mentally retarded , psychiatry , medicine , clinical psychology , developmental psychology , receptor
Self‐injurious behaviour (SIB) amongst people with learning disabilities is very common and is often difficult to treat. This study supports the theory that serotonin is involved in the development of SIB in these individuals. Twelve patients suffering from mild to severe mental retardation were treated with either fluoxetine or fluvoxamine. Ten of them showed marked improvement of their SIB, clinically as well as objectively (according to scores on the adaptive behaviour scale). The treatment had to be discontinued in the other two patients because of the development of severe adverse effects to the medication. The results of this study are therefore in line with previous studies showing the effectivity of Selective Serotonin Re‐uptake Inhibitors in the treatment of SIB in mentally retarded individuals. © 1998 John Wiley & Sons, Ltd.