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Psychological predictors of CCK 4 ‐induced panic‐like symptoms
Author(s) -
Jerabek Ilona,
Boulenger JeanPhilippe,
Lavallée YvonJacques,
Jolicoeur François B.
Publication year - 1998
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/(sici)1099-1077(199801)13:1<35::aid-hup948>3.0.co;2-g
Subject(s) - placebo , panic , beck depression inventory , anxiety , psychology , state trait anxiety inventory , psychiatry , clinical psychology , depression (economics) , panic disorder , trait anxiety , beck anxiety inventory , medicine , alternative medicine , pathology , economics , macroeconomics
The present study investigated whether psychosomatic reaction to panicogenic CCK 4 administration can be predicted based on basal and pre‐administration psychological traits and characteristics. Sixteen healthy volunteers participated in a double‐blind, placebo‐controlled cross‐over experiment in which they were subjected to CCK 4 and placebo challenge. One week prior to experimentation, they completed a battery of self‐administered psychological inventories, including the trait form of State‐Trait Anxiety Inventory (STAI‐T), Chambless Anxious Cognitions Inventory (CACI), Beck Depression Inventory (BDI) and the Symptom Checklist 90 (SCL‐90). The state form of STAI (STAI‐S) was administered before and after the injections of CCK 4 (25 μg i.v.) and placebo. Various elements of the panic‐like experience (latency and duration of symptoms, number and intensity of symptoms, fear of symptoms, and post‐administration state anxiety) were recorded after both injections. The results of multiple regression analyses suggest that basal STAI‐S, STAI‐T and BDI are very good predictors of the number and intensity of CCK 4 ‐induced symptoms, the fear reaction to panic symptoms and post‐injection state‐anxiety. The SCL‐90 scores were retained as the best predictor of placebo‐induced panic‐like symptoms. We conclude that substantial portions of variability in CCK 4 and placebo‐induced panic‐like reaction can be explained by basal psychological characteristics. © 1998 John Wiley & Sons, Ltd.