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Activation of central 5HT1B receptors increases locomotor activity in mice
Author(s) -
O'Neill Michael F.,
Fernández Andrés G.,
Palacios José M.
Publication year - 1997
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/(sici)1099-1077(199709/10)12:5<431::aid-hup884>3.0.co;2-o
Subject(s) - locomotor activity , antagonist , receptor , chemistry , receptor antagonist , pharmacology , in vivo , medicine , endocrinology , biology , microbiology and biotechnology
The effects of 5‐HT1B/D receptor agonists anpirtoline, S‐CM‐GTNH2 and CP93129 were examined in locomotor activity tests in mice. Anpirtoline and S‐CM‐GTNH2 both significantly increased locomotor activity (ambulation) (minimum affective doses; 3 and 30 mg/kg respectively). CP 93129 injected subcutaneously was without effect, but increased locomotor activity when given i.c.v. Thus activation of central 5‐HT1B receptors results in increased locomotor activity. The effects of anpirtoline and S‐CM‐GTNH2 were blocked by the antagonist GR 127935 suggesting that GR 127935 is an effective antagonist of 5‐HT1B receptors in vivo . © 1997 John Wiley & Sons, Ltd.