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The effects of acute doses of dothiepin (25, 50, and 75 mg) versus placebo on psychomotor performance and cognitive function
Author(s) -
Dal Pozzo C.,
Kerr J. S.,
Balguranidis C.,
Yoon J. S.,
Hindmarch I.
Publication year - 1997
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/(sici)1099-1077(199707/08)12:4<337::aid-hup873>3.0.co;2-h
Subject(s) - psychomotor learning , flicker fusion threshold , placebo , crossover study , anesthesia , medicine , sedation , cognition , audiology , effects of sleep deprivation on cognitive performance , psychology , psychiatry , flicker , alternative medicine , pathology , electrical engineering , engineering
Sixteen healthy volunteers received dothiepin 25 mg, 50 mg, 75 mg and placebo in a double‐blind crossover study. Each subject received the four treatments once, with a 6‐day washout period between test days. On each occasion psychomotor performance and cognitive function were measured 30 min before dosing and 1, 2, 4, 6 and 8 h after drug administration. The test battery comprised: Critical Flicker Fusion, Choice Reaction Time, Continuous Tracking and Short Term Memory. Subjective ratings of sedation were measured using Line Analogue Rating Scales. Dothiepin at the subtherapeutic dose of 75 mg was shown to produce statistically significant impairment ( p <0·05) on several of the variables investigated. These included CFF at the 2‐ and 4‐h test points, TRT at the 2‐h test point and LARS at the 2‐ and 4‐h test points. Lower doses also produced impairment of cognitive function and psychomotor performance as measured by the present test battery. © 1997 John Wiley & Sons, Ltd.