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The Coincidence of Schizophrenia and Idiopathic Parkinson's Disease: Successful Treatment with a Combination of Antiparkinsonian Drugs and Atypical Antipsychotic Drugs
Author(s) -
WATANABE MASAYUKI,
KODAMA YOSHIO,
SHIMIZU KUNIO,
ICHINOWATARI NAOMICHI
Publication year - 1997
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/(sici)1099-1077(199705/06)12:3<271::aid-hup861>3.0.co;2-f
Subject(s) - bromocriptine , dopaminergic , parkinson's disease , antipsychotic , medicine , schizophrenia (object oriented programming) , thioridazine , sulpiride , parkinsonism , atypical antipsychotic , psychosis , psychology , disease , psychiatry , dopamine , pharmacology , chlorpromazine , prolactin , hormone
It is rare for schizophrenia and idiopathic Parkinson's disease to occur in the same patient. This report describes a case in which a chronic schizophrenic patient later developed idiopathic Parkinson's disease. Both the psychotic and the parkinsonian symptoms of the patient were well controlled with the combination of antiparkinson drugs (bromocriptine and L ‐threo‐DOPS) and atypical antipsychotic drugs (sulpiride and thioridazine). It is suggested that excessive dopaminergic activity in the mesolimbic system may coexist with dopaminergic deficiency in the nigrostriatal system in this patient. © 1997 John Wiley & Sons, Ltd.