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Psychiatry, psychopharmacology and P‐450s
Author(s) -
Glue Paul,
Banfield Christopher
Publication year - 1996
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/(sici)1099-1077(199603)11:2<97::aid-hup759>3.0.co;2-7
Subject(s) - psychopharmacology , drug , pharmacology , psychotropic drug , medicine , enzyme , cytochrome p450 , pharmacokinetics , psychiatry , biology , biochemistry
The cytochrome P‐450 enzyme family is one of the major drug metabolizing systems in man. Over the last decade, advances in molecular biology, in vitro and clinical pharmacology techniques have increased our understanding of their role in the metabolism of psychotropic drugs, the effects of psychotropics on enzyme inhibition and induction, and how the pharmacokinetics of psychotropics are affected by changes in enzyme activity. There is also greater awareness of the influence of factors such as age, gender, race and environment on enzyme activity. This information can be of considerable assistance to psychiatrists, to help with rational prescribing, or to prevent or minimize the potential for drug interactions.