Premium
Serum Thyrotropin responses to Thyrotropin‐Releasing Hormone in medium‐ and long‐term abstinent alcohol dependent patients
Author(s) -
O’Hanlon M.,
Scull D.,
Whitehouse S.,
Kahn A.,
Dinan T. G.
Publication year - 1996
Publication title -
human psychopharmacology: clinical and experimental
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.461
H-Index - 78
eISSN - 1099-1077
pISSN - 0885-6222
DOI - 10.1002/(sici)1099-1077(199601)11:1<33::aid-hup741>3.0.co;2-k
Subject(s) - thyrotropin releasing hormone , trh stimulation test , abstinence , medicine , hormone , endocrinology , stimulation , psychology , psychiatry
Twenty‐three euthymic alcoholics in medium‐ and long‐term abstinence were studied as were 20 healthy controls. All underwent a Thyrotropin Releasing Hormone/Thyrotropin Stimulating Hormone (TRH/TSH) stimulation test. Ninety per cent of medium‐term abstinent and 100 per cent of long‐term abstinent alcoholics had a response within the normal range. However, overall, the TSH responses to TRH were significantly less than in controls. Our study suggests that while there is some improvement in TRH/TSH responses in long‐term abstinent patients, there is still evidence of hypo function in those over 1 year alcohol‐free.