Premium
Coagulation patterns of disseminated intravascular coagulation in acute promyelocytic leukemia
Author(s) -
Higuchi Takakazu,
Shimizu Toru,
Mori Hiraku,
Niikura Haruo,
Omine Mitsuhiro
Publication year - 1997
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/(sici)1099-1069(199711)15:4<209::aid-hon615>3.0.co;2-s
Subject(s) - disseminated intravascular coagulation , acute promyelocytic leukemia , medicine , fibrinogen , chemotherapy , coagulation , antithrombin , gastroenterology , platelet , leukemia , coagulopathy , immunology , retinoic acid , heparin , biology , biochemistry , gene
Coagulation patterns of 19 newly‐diagnosed acute promyelocytic leukemia (APL) patients with disseminated intravascular coagulation (DIC) at presentation were studied. Seventeen patients had hemorrhagic complications, of which four were fatal. Fatal hemorrhages were related with lower fibrinogen level and lower platelet count. DIC of the APL patients without infection was characterized by low fibrinogen and normal antithrombin III (ATIII) level. Thrombin–ATIII complex level was elevated in all patients examined. Patients with infection had higher fibrinogen levels than those without infection and some patients had reduced ATIII level. Ten remission inductions were tried with multidrug chemotherapy and seven with all‐ trans retinoic acid (ATRA). Complete remission was achieved in seven of ten inductions with chemotherapy and in all seven inductions with ATRA. Two patients treated with chemotherapy had fatal hemorrhage after starting therapy but none treated with ATRA. © 1997 John Wiley & Sons, Ltd.