Premium
Exacerbation of coagulopathy with concurrent bone marrow necrosis, hepatic and renal dysfunction secondary to all‐trans retinoic acid therapy for acute promyelocytic leukemia
Author(s) -
Cull Gavin M.,
Eikelboom John W.,
Cannell Paul K.
Publication year - 1997
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/(sici)1099-1069(199702)15:1<13::aid-hon593>3.0.co;2-s
Subject(s) - coagulopathy , acute promyelocytic leukemia , medicine , exacerbation , bone marrow , necrosis , retinoic acid , bone marrow suppression , gastroenterology , tretinoin , chemotherapy , immunology , biology , biochemistry , gene
A 22‐year‐old female presented with acute promyelocytic leukemia (APL). Treatment with all‐trans retinoic acid (ATRA) resulted in a severe exacerbation of the coagulopathy 5 days after its introduction. This was complicated by bone marrow necrosis, parenchymal liver damage and acute tubular necrosis. Temporary cessation of the drug and subsequent dose reduction was effective in controlling the coagulopathy. © 1997 John Wiley & Sons, Ltd.