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AGGRESSIVE NON‐HODGKIN'S LYMPHOMA: T‐CELL VERSUS B‐CELL
Author(s) -
LIANG RAYMOND,
TODD DAVID,
HO FAITH C. S.
Publication year - 1996
Publication title -
hematological oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 44
eISSN - 1099-1069
pISSN - 0278-0232
DOI - 10.1002/(sici)1099-1069(199603)14:1<1::aid-hon555>3.0.co;2-y
Subject(s) - lymphoma , cancer research , b cell , medicine , immunology , antibody
This study aimed to define the clinical characteristics, treatment outcome and independent prognostic factors of 144 patients with T‐ and 357 B‐cell non‐Hodgkin's lymphomas. Entities with well‐defined immunophenotype and clinical characteristics were excluded. Patients with T‐cell tumours were younger. T‐immunophenotype was associated with more advanced disease and presence of B symptoms. They were also less likely to have bulky disease. Primary nasal lymphomas were usually T‐cell while lymphomas arising from the gastrointestinal tract and Waldeyer's ring were mostly B‐cell. On univariate analysis, T‐immunophenotype was associated with lower CR rate, higher relapse rate and inferior overall survival. On the other hand, multivariate analysis revealed that advanced stage, presence of B symptoms, advanced age, high serum lactate dehydrogenase level and use of non‐doxorubicin‐containing regimens for induction were associated with poor prognosis. Immunophenotype was not a significant independent prognostic factor.