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Inhibitory effect of Cordyceps sinensis and Cordyceps militaris on human glomerular mesangial cell proliferation induced by native LDL
Author(s) -
ZhaoLong Wu,
XiaoXia Wang,
WeiYing Cheng
Publication year - 2000
Publication title -
cell biochemistry and function
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 61
eISSN - 1099-0844
pISSN - 0263-6484
DOI - 10.1002/(sici)1099-0844(200006)18:2<93::aid-cbf854>3.0.co;2-#
Subject(s) - cordyceps militaris , cordyceps , traditional medicine , biology , chemistry , medicine
Native LDL, in low concentrations, promotes proliferation of cultured human glomerular mesangial cells. LDL stimulated [ 3 H]‐thymidine incorporation into DNA of human glomerular mesangial cells. Increased concentrations of LDL led to increased [ 3 H]‐thymidine incorporation. When LDL concentrations were 5, 10 and 50 μg ml −1 , [ 3 H]‐thymidine incorporation was 919·5±216, 1106±132, and 1200±210, respectively. When Cordyceps sinensis 100, 200, 300, 400 μg ml −1 plus LDL 10 μg ml −1 were added, [ 3 H]‐thymidine incorporation was 99±19 and 53±8, respectively, P <0·01 compared with controls. With Cordyceps militaris at similar concentrations plus LDL 10 μg ml −1 , [ 3 H]‐thymidine incorporation was respectively 192±75, 168±66, 145±53 and 72±16, P <0·01 compared with controls. The data suggest that LDL may play a critical role in mediating mesangial cell hypertrophy or proliferation involved in the development of glomerulosclerosis. Cordyceps sinensis and Cordyceps militaris inhibited, to a certain degree, proliferation of cultured human glomerular mesangial cell induced by LDL. Copyright © 2000 John Wiley & Sons, Ltd.